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Formation of inclusion bodies disrupts cell homeostasis, axonal transport, synaptic receptor activity, and neurotransmitter release (Ehlers, 2013), and also results in mitochondrial swelling and damage (Maharjan et al., 2014), impaired cell differentiation, degeneration, and neuronal death via apoptosis or necrosis (Schwartz and Ciechanover, 2009

Timing Optional Monitoring guidance is pathway-based and broad because NAD+ protocols do not have established clinical lab-response markers

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